NCI is revolutionizing nutritional clinical trials by dramatically reducing costs, speeding up clinical evaluations while providing cutting edge scientific support for product claims.
A. Acute clinical studies are perform to verify the rapid effect of tested material on blood level or blood enzyme activity of selected targets. Acute clinical testing is performed on fasting human subjects according to accepted inclusion criteria. This type of work allows finding out:
A.1. Minimum effective dose (MED)
A.2. Target-specific activity
A.3. Biomarker response
A.4. Bioavailability of active entities present in tested material
B. Non-acute clinical discovery studies are designed to present short-term target-specific activity of tested material. All molecular targets activity tests offered by NCI are associated with conditions such as:
B.1. Metabolic Syndrome
B.2. Hyperglycemia
B.3. Hyperlipidemia
B.4. Inflammatory conditions
B.5. Weight control
B.6. Bone and joint health
B.7. Blood pressure
B.8. Aging
Clinical Tests
C.1. Serum enzyme activity tests
- ACE
- CETP
- Elastase
- PON1
- Elastase
C.2. Serum biomarkers
- CRP
- Insulin
- Cytokines and chemokines
- Glucose
- LDL/HDL
- Triglycerides
- Total cholesterol
C.3. Serum chemistry
- Organic and inorganic chemistry
- MPO
- Isoprostanes
- Calcidiol
- Calcitriol
- Calcitonin
- Oxidation products
- AOPP
- oxLDL
- Carbonyl proteins
- Adipokines
- DHEA
- DHEA-S
- Testosteron
- IgE
- TSLC
- Serum ORAC
C.4. Subjective clinical evaluations
C.1 McGill Questionnaire to evaluate pain level
C.2 Satiety and appetite suppression evaluations
C.3 Here we can add few more published and relatively well established subjective evaluation systems